de Oliveira Marreiros DJ, Lokhorst MM, Young-Afat DA, et al. Measuring health-related quality of life in patients with peripheral vascular malformations with PROMIS® computerized adaptive tests. J Plast Reconstr Aesthet Surg. 2025;106:401-408. doi:10.1016/j.bjps.2025.05.036

This prospective cohort study examined adults with vascular malformations to determine if PROMIS CATs can reliably measure HRQoL for this patient population. 123 patients completed at least one CAT and 55 patients completed the retest of a least one CAT. Reliability for test-retest was quantified by intraclass correlation coefficients, with an ICC >/= to 0.77 being considered adequate. Standard errors of measurement and smallest detectable change were also calculated. Of all patients sampled, all achieved an ICC above 0.85, SEM under 5 points and SDC around 10 points. This study indicated adequate test-retest reliability and measurement errors. In adults with vascular malformations, PROMIS CATs are reliable for measuring physical, mental and social HRQoL outcomes.

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Yakdan S, Frumkin MR, Javeed S, et al. Defining Substantial Clinical Benefits of PROMIS Pain Interference and Physical Function in Patients Undergoing Lumbar and Thoracolumbar Spine Surgery. Spine (Phila Pa 1976). Published online January 30, 2025. doi:10.1097/BRS.0000000000005276

This prospective study was the first to define Substantial Clinical Benefit (SCB) thresholds for PROMIS Physical Function (PF) and PROMIS Pain Interference (PI) in the thoracolumbar/lumbar spine surgery population. The study included 137 patients age 21-85yo with a numeric rating of back pain of at least 3/10, undergoing lumbar/thoracolumbar surgery for degenerative spine disease. SCB thresholds were calculated using anchor-based methods with ODI and NASS index as anchors, with ROC analysis used to determine optimal SCB cutoffs. The thresholds defined in this study will assist in evaluating patient outcomes for spine surgery.

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Austenfeld EM, Sabbagh SE, Liegl M, et al. PROMIS displays strong construct validity in pediatric and adult patients with idiopathic inflammatory myopathies. Rheumatology. 2026;65(1):keaf502. doi:10.1093/rheumatology/keaf502

Austenfeld et al studied the validity of PROMIS for juvenile and adult onset idiopathic inflammatory myopathies (JIIM/IIM) to examine if there were any associations with disease characteristics and assessments. The study administered PROMIS-49 or -57 assessments by 70 parents, 49 pediatric patients and 61 adult patients with IIM. Legacy health related quality of life (HRQoL) instruments were used to evaluate construct validity. This study concluded that PROMIS offers a view of HRQoL measures that is more nuanced, and may be more sensitive than legacy HRQoL measures, and support incorporating PROMIS in the assessment of IIM/JIIM.